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” said Michelle. It must be very strange promoting Jab Tak Hai Jaan after Yash (Chopra) ji? I? donors can review requests,Facebook will automatically notify nearby blood donors as well as spread the word.” Holley said.Mir and Jigar on All shlf1314 Radio, But sites with hydrothermal systems have also become popular among the scientists—sites such as Columbia Hills and those near Isidis Basin. It won’t have,C. newsletter reported that Potti had falsely claimed to be a Rhodes Scholar more than 30 statisticians and bioinformaticians wrote to NCI Director Harold Varmus asking NCI to investigate Varmus requested the IOM study and Duke launched a new investigation and halted the trials a second time IOM found many potential problems inherent in tests based on omics which it defines as research that looks for patterns in large sets of molecules such as proteins DNA RNA or metabolites Such tests offer great potential for guiding patient care but because they can be difficult to reproduce fewer than expected have reached the clinic the report notes One major problem the report says is "overfitting": Because the studies often look for patterns in hundreds of biomolecules using a relatively small number of patient samples it is easy to find correlations that do not reflect the biology of patients’ disease The report recommends a set of steps to validate the tests such as repeating the test on blinded samples from a different institution Journals and funders should also require that data and models from papers be made freely available so that other researchers can check the results Before evaluating the test in the clinic researchers need to "lock down" or freeze the computational model used so that it cannot be changed the report says The researchers should also consult with the Food and Drug Administration (FDA) long before they use the test in a clinical trial—which Duke did not do And FDA needs to clarify its requirements The IOM committee also found problems with oversight at Duke where "multiple systems put in place . to ensure the integrity and rigor of the scientific process failed" A 31-page appendix offers a blow-by-blow account of what happened at Duke It notes that financial conflicts of interest (Duke investigators had patents on technology and ties to companies developing the tests) and deference to a senior professor may have influenced the university to dismiss concerns about the papers Duke attributed its failure to "missed signals" To avoid these problems institutions need to strengthen their oversight of conflicts of interest and processes for responding to questions about published research MD Anderson’s Baggerly says his initial read of the report is "quite positive" If the recommendations had all been in place "I suspect many of the problems encountered might have been short-circuited" he says The NCI’s Lisa McShane who spent months herself trying to validate Duke results says the IOM committee "did a really fine job" in laying out the issues NCI now plans to require that its cooperative groups who want to use omics tests follow a checklist similar to that in the IOM report NCI has not yet decided whether it should add new requirements for omics tests to its peer review process for investigator-initiated grants But "our hope is that this report will heighten everyone’s awareness" McShane says In a statement Duke said it "greatly appreciate[s] the thoughtful and thorough work done by the IOM committee" and expects to incorporate the recommendations into "ongoing efforts to strengthen the rigor of our research enterprise We have learned from our situation" the statement says Potti left Duke in 2010 and later joined a medical practice in South Carolina but after 60 Minutes aired a segment about the controversy in February he was let go A scientific misconduct investigation at Duke is ongoing according to the university

are already moving to do; and create a network of “physical sciences-oncology centers” to bring together nanobiology, John Niederhuber.

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